Kalyan Giri
Assistant Professor
About-
My Research interest is to build a significant research program on the structure and function of HIV-1 accessory proteins that are essential for HIV infection. The HIV-1 genome encodes four accessory proteins that include Vif, Nef, Vpu and Vpr. These proteins employ an array of strategies to manipulate host cellular factors and distinguish HIV-1 as a complex retrovirus. The goal of this research is to determine the mechanisms by which HIV accessory proteins recruit their cellular binding partners, pinpoint the molecular interactions that stabilize the virus-host protein complexes, and develop biochemical assays to screen for molecules that inhibit complex formation. This approach will lead to a more detailed understanding of accessory protein structure and function and will open avenues for the development of a new class of antiretroviral drugs.
Qualifications+
M.Sc. Physics (Jadavpur University, 1999)
Post-MSc Biophysical Sciences (Saha Institute of Nuclear Physics, 2000)
PhD Biophysical Sciences (Saha Institute of Nuclear Physics, 2006)
Biography+
2013 - present : Assistant Professor, Department of Life Sciences, Presidency University, Kolkata
2007- 2013 : Research Associate, Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Maryland, USA
Research / Administrative Experience+
Teaching / Other Experience+
2013 - present : Department of Life Sciences, Presidency University
Post Graduate Supervision+
Academic Memberships+
Publications+
Chaudhuri D, Majumder S, Datta J, Giri K (2023) Exploring the chemical space for potential inhibitors against cell surface binding protein of Mpox virus using molecular fingerprint based screening approach. Journal of Biomoleular Structure and Dynamics https://doi.org/10.1080/07391102.2023.2238087
Majumder S, Deganutti G, Pipitò L, Chaudhuri D, Datta J, Giri K (2023) Computer-aided de novo design and optimization of novel potential inhibitors of HIV-1 Nef protein. Computational Biology and Chemistry 104:107871
Chaudhuri D, Datta J, Majumder S, Giri K (2023) Repurposing of drug molecules from FDA database against Hepatitis C virus E2 protein using ensemble docking approach. Molecular Diversity doi: 10.1007/s11030-023-10646-2.
Datta J, Majumder S, Chaudhuri D, Giri K (2023) In silico investigation of binding propensity of hematoxylin derivative and damnacanthal for their potential inhibitory effect on HIV-1 Vpr from different subtypes.Journal of Biomoleular Structure and Dynamics https://doi.org/10.1080/07391102.2023.2184634
Saha J, Chaudhuri D, Kundu A, Bhattacharya S, Roy S, Giri K (2023) Phylogenetic, structural, functional characterisation and effect of exogenous spermidine on rice (Oryza sativa) HAK transporters under salt stress. Functional Plant Biology 50:160-182
Sarkar D, Majumder S, Giri K, Sabnam N (2022) In silico characterization, molecular docking, and dynamic simulation of a novel fungal celldeath suppressing effector, MoRlpA as potential cathepsin B-like cysteine protease inhibitor during rice blast infection. Journal of Biomoleular Structure and Dynamics https://doi.org/10.1080/07391102.2022.2139763
Chaudhuri D, Datta J, Majumder S, Giri K (2022) In silico study on miRNA regulation and NSs protein interactome characterization of the SFTS virus. Journal of Molecular Graphics and Modelling 117:108291
Chaudhuri D, Datta J, Majumder S, Giri K (2022) Prediction of infectivity of SARS?CoV?2 virus based on Spike?hACE?2 interaction. VirusDisease 33:244-250
Chaudhuri D, Majumder S, Datta J, Giri K (2022) Designing of nanobodies against Dengue virus Capsid: a computational affinity maturation approach.Journal of Biomoleular Structure and Dynamics 41(6):2289-2299
Majumder S, Giri K (2021) An insight into the binding mechanism of Viprinin and its morpholine and piperidine derivatives with HIV-1 Vpr: molecular dynamics simulation, principal component analysis and binding free energy calculation study. Journal of Biomoleular Structure and Dynamics 40(21):10918-10930
Chaudhuri D, Majumder S, Datta J, Giri K (2021) In silico study of mutational stability of SARS-CoV-2 proteins. The Protein Journal 40: 328-340
Majumder S, Chaudhuri D, Datta J, Giri K (2020) Exploring the intrinsic dynamics of SARS-CoV-2, SARS-CoV and MERS-CoV spike glycoprotein through normal mode analysis using anisotropic network model. Journal of Molecular Graphics and Modelling 102:107778
Chaudhuri D, Datta J, Majumder S, Giri K (2020) In silico designing of peptide based vaccine for Hepatitis viruses using reverse vaccinology approach. Infection, Genetics and Evolution 84: 104388
Saha J, Giri K, Roy S (2020) Identification and characterization of differentially expressed genes in the rice root following exogenous application of spermidine during salt stress. Genomics 112: 4125–4136
Saha J, Giri K (2017) Molecular phylogenomic study and the role of exogenous spermidine in the metabolic adjustment of endogenous polyamine in two rice cultivars under salt stress. Gene 609: 88–103
Giri K, Scott R, Maynard E (2009) Molecular Structure and Biochemical Properties of the HCCH-Zn2+ Site in HIV-1 Vif. Biochemistry 48: 7969-7978.
Giri K, Maynard E (2009) Conformational analysis of a peptide approximating the HCCH motif in HIV-1 Vif. Biopolymers: Peptide Science 92: 417-425.
Ghosh U, Giri K, Bhattacharyya N P (2009) Interaction of Aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, Reverse transcriptase and Taq polymerase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 74: 1145-1151.
Raychaudhuri S, Majumder P, Sarkar S, Giri K, Mukhopadhyay D, Bhattacharyya N P (2008) Huntingtin interacting protein HYPK is intrinsically unstructured. Proteins 71: 1686-1698.
Giri K, Bhattacharyya N P, Basak S (2007) pH-dependent self-assembly of polyalanine peptides. Biophysical Journal 92: 293-302.
Giri K, Ghosh U, Bhattacharyya N P, Basak S (2003) Caspase 8 mediated apoptotic cell death induced by β-sheet forming polyalanine peptides. FEBS Letters 555: 380-384.
Address
Presidency University,
86/1 College Street,
Kolkata - 700073,
West Bengal, India
Email: kalyan.biochem at presiuniv.ac.in
alternate E-mail: kalyan.giri at gmail.com
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