Supratim Mandal

Associate Professor

PhD. Zoology, 2018, West Bengal State University, Kolkata, India

M.Sc. Microbiology, 2007, University of Calcutta, Kolkata, India

B.Sc. Microbiology, 2005, Acharya Prafulla Chandra College, Calcutta University of Calcutta, Kolkata, India

In the current times, global health is plagued by the emergence of difficult to treat, multidrug-resistant infections, which constitute a major share of the annual mortality, worldwide. Antimicrobial resistance (AMR) claims around 0.7 million lives annually, and, if left un-intervened, this figure is expected to rise to ten million by 2050.The rising resistance against the backdrop of fewer approved antibiotics every year, calls for urgent measures by the scientific community to develop new drugs, with lesser or negligible propensity of resistance development by bacteria. Developing and designing novel and promising strategies to counteract antimicrobial resistance (AMR) is the main goal of my research. In order to tackle multidrug resistance, my research group works on the synthesis and characterisation of novel chemicals, metal conjugated synthetic complexes and therapeutic strategies. In addition, I am well acquainted in the field of parasitology, immunology, cell biology, cancer biology and other associated fields. My primary research areas include design, synthesis and characterization of heavy metal-conjugated particles and advanced drug delivery systems to overcome antibacterial resistance with giving emphasis against microbial biofilms. Furthermore, my research also emphasizes on isolation and characterization of novel natural compounds for treating microbial infections. I currently focus on investigation of the molecular approaches of microbial biofilm machinery and identification of the selective drug targets for biofilm disruption and disease prognosis. My research group currently aims to specifically design inhibitors for bacterial enzymes to downregulate bacterial resistance machinery, overcoming AMR with promising therapeutic intervention. Recently, I have focused on developing protective coatings with the novel drug conjugates for the eradication of medicinal implant associated diseases with potent outcome. The promising results have enlightened the research to a more enriched pathway proposing an alternative way for the management of microbial biofilms and lethal disease scenario. In addition, I am also interested in investing the role of microbiome in antimicrobial resistance. 

I have started my career in the field of Microbiology after joining as an Assistant Professor at the Department of Microbiology, Acharya Prafulla Chandra College, West Bengal State University. Then I have joined at the Department of Microbiology, University of Kalyani and started my journey as researcher in the field of Antimicrobial Resistance Research and Experimental Therapeautics against Biofilm mediated infections. 

Then I have joined as an Associate Professor at the Institute of Health Sciences, Presidency University, Kolkata. My future aspiration is to train a group of highly motivated students and research scholars in the field of drug development and antimicrobial therapeutics. In addition, my goal is to develop an integrated modern research facility and environment in the field of Antimicrobial Drug Resistance. The benefits that such technology would accord to our clinicians in fighting the upcoming resistant pathogens, and the innumerable lives that drugs, products and technology developed thenceforth, does warrant an intense, insightful and urgent inquiry into it, which serves as my main motivation.

Administrative Experiences:

1.     Member, Departmental Research Committee, University of Kalyani.

2.     Member, Post Graduate Board of Studies, University of Kalyani.

3.     Member, Academic and Administrative Departments for All India Survey on Higher Education (AISHE) committee, University of Kalyani.

4.     Member, Committee for Webinars and Scientific Lecture Series, University of Kalyani.

5.     Member,Newsletter Committee, University of Kalyani.

6.     Member, Institutional Innovation Council, University of Kalyani. 

7.     Member, Board of Studies, Institute of Health Sciences, Presidency University.

8.     Member, DAC, Institute of Health Sciences, Presidency University.

Teaching Experience:

1. Associate Professor: April 2026-current; Institute of Health Sciences, Presidency University, Kolkata, India

2. Assistant Professor: July 2018-April 2026. Department of Microbiology, University of Kalyani, Kalyani, Nadia.

3. Assistant Professor: April 2010 – July 2018; Department of Microbiology, Acharya Prafulla Chandra College, Kolkata.

Ph.D. Awarded from the University of Kalyani

Name: Samik Biswas

Title of thesis: Studies on the antibacterial and anticancer activities of a mononuclear copper (II) schiff base isothiocyanato compound.

Year in which awarded: 2024

Registered Ph.D. Student:

Shrabasti Bandyopadhyay (DST INSPIRE-SRF)

Indrajit Das (ANRF-SRF)

Post-Doctoral Fellow : Dr. Samik Biswas (ICMR)

1.     Member, American Society for Investigative Pathology.

2.     Member, European Society for Medical Oncology.

3.     Life Member, Indian Science Congress Association.

A. Research Articles:

1.     Wasai A, Roy A*, Barua M, Ghosh P, Saxena A, Boulaamane Y, Goyal N, Chandra A, Koner SN, Saha S*, Saha B, Pore SK, Rizzoli C, Mandal, S*. Anti-cancer and dual inhibitory potential of PI3K/AKT and Ras/MAPK/ERK signalling of a novel zinc (II) trinuclear complex with tetradentate schiff base ligand and azido ion in prostate adenocarcinoma: synthesis, in silico and in vitro evaluation. Journal of Molecular Structure. 2026 May; 145636.

2.     Ruidas P, Goswami M, Das D, Midya R, Dhibar S, Neogi P, Ghosh NN, Saha S, Das S, Singh S, Mondal P, Mandal S, Bhattacharyya S, Ghosh A*, Sarkar K*, Bhattacharjee S*. Regioisomer-specific, self-healing, and moldable supramolecular hydrogel fabrication: chiroptical tuning, biocompatibility, cell attachment, and bacteria-infected wound healing topical applications. Nanoscale. 2026 Jan; 18(8), 4186-4198.

3.     Sarkar C, Bandyopadhyay S, Ghosh T, Mandal S*, Bera M*. Exploiting Metal–Ligand Coordination Compounds against Multidrug-Resistant Bacterial Infections by Inhibiting Microbial Growth and Disrupting Biofilm Formation. ACS Applied Engineering Materials. 2026 Jan 20.

4.     Sarkar P, Das S, Bandyopadhyay S, Gopi P, Biswas S, Tribedi P, Pandya P, Mandal S, Bhadra K*. Beta Carboline Alkaloid Harmine as Biofilm Inhibitor: In vitro, in Silico and in Vivo Studies Suppressing Growth and Virulence-Related Factors Against Resistant Staphylococcus Aureus. Applied Biochemistry and Biotechnology. 2025 Dec;1-38.

5.     Tyagi K, Jain P*, Roy A*, Mandal S. Deciphering the transcriptional alterations in high grade serous ovarian cancer upon catalytic inactivation of protein kinase D. International journal of biological macromolecules. 2025 Aug; 319, 145234.

6.     Biswas S, Sk S, Das S, Das I, Bandyopadhyay S, Mondal S, Ali SI*, Mandal S*, Bera M*. Design and Synthesis of Bimetallic Cu (II) Compounds as Potent Antibacterial and Antibiofilm Agents with Metallo?β?Lactamase Inhibitory Activity against Multidrug Resistant Pseudomonas aeruginosa. Chemistry–A European Journal. 2025 July; 31(41): e202501313.

7.     Paul S, Biswas S, Choudhuri T, Bandyopadhyay S, Mandal, S*, Bagdi A. K*. I2-Catalyzed Cascade Annulation/Cross-Dehydrogenative Coupling: Excellent Platform to Access 3-Sulfenyl Pyrazolo [1, 5-a] pyrimidines with Potent Antibacterial Activity against Pseudomonas aeruginosa and Staphylococcus aureus. ACS Applied Bio Materials, 2025; 8(4), 3254-3269.

8.     Sk S, Bandyopadhyay S, Sarkar C, Das I, Gupta A, Sadangi M, Mondal S, Banerjee M, Vijaykumar G, Behera JN, Konar S, Mandal S*, Bera M*. Unraveling Multicopper [Cu3] and [Cu6] Clusters with Rare μ3-Sulfato and Linear μ2-Oxido-Bridges as Potent Antibiofilm Agents against Multidrug-Resistant Staphylococcus aureus. ACS Applied Bio Materials. 2024 Mar 13;7(4):2423-49.

9.     Bandyopadhyay S, Naskar A, Acharya K*, Mandal S*. Antibiofilm and antivirulence efficacy of Pleurotus platypus methanolic extract against Staphylococcus aureus through ROS generation and cell membrane disruption. Microbial Pathogenesis. 2024 Nov 1; 196:106992.

10.  Das S, Sen B, Sarkar S, Das I, Sepay N, Paul S, Mandal S, Roy A, Malecka M, Abbas SJ, Gangavarapu RR, Vijayakumar B, Ali SI*. Design, Synthesis, and Characterization of Polyoxotungstate-Decorated Ionic Liquid–Based Hybrid Material,[BmIm] 4 [SiW12O40] toward Rapid Adsorption of Dye and Antibacterial Activities. Inorganic Chemistry. 2024 Sep 16;63(39):18448-67.

11.  Sarkar C, Majumder A, Das I, Maji S, K?ak J, Vijaykumar G, Mandal S, Bera M*. Crystal structure, ferromagnetic coupling and antibacterial activity of a new family of dicopper (II) complexes supported by auxiliary para-substituted benzoate linkers. Journal of Molecular Structure. 2024 Dec 15; 1318:139423.

12.  Barua M, Bandyopadhyay S, Wasai A, Ghosh M, Roy I, Ghosh P, Koner S, Rizzoli C, Roy A*, Saha S*, Mandal S*. A trinuclear Zn (II) schiff base dicyanamide complex attenuates bacterial biofilm formation by ROS generation and membrane damage and exhibits anticancer activity. Microbial Pathogenesis. 2024 Mar 1;188:106548.

13.  Sachdeva A, Roy A*, Gupta MK, Mandal S. Pharmacological inhibition of Protein kinase D2/Aurora kinase A signalling axis suppresses G2/M cell cycle progression and proliferation of epithelial ovarian cancer cells. Pathology-Research and Practice. 2024 Jun 12:155390.

14.  Tyagi K, Roy A*, Mandal S. Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer. Molecular Biology Reports. 2024 Sep 14;51(1):983.

15.  Sachdeva A, Roy A*, Mandal S. Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer. Molecular and Cellular Biochemistry. 2024 Apr 1:1-3.

16.  Dastidar DG*, Roy A, Ghosh G, Mandal S. Applications of Inorganic Nanomaterials against Tuberculosis: A Comprehensive Review. Current Drug Delivery. 2024.

17.  Tyagi K, Roy A*, Mandal S. Pharmacological inhibition of protein kinase D suppresses epithelial ovarian cancer via MAPK/ERK1/2/Runx2 signalling axis. Cellular Signalling. 2023 Oct 1;110:110849.

18.  Biswas S, Wasai A, Ghosh M, Rizzoli C, Roy A*, Saha S*, Mandal S*. A mononuclear N, N, N, O donor schiff base Cu (II) complex inhibits bacterial biofilm formation and promotes apoptosis and cell cycle arrest in prostate cancer cells. Journal of Inorganic Biochemistry. 2023 Oct 1;247:112314.

19.  Roy A*, Chauhan S, Bhattacharya S, Jakhmola V, Tyagi K, Sachdeva A, Wasai A, Mandal S. Runt-related transcription factors in human carcinogenesis: a friend or foe?. Journal of Cancer Research and Clinical Oncology. 2023 Sep;149(11):9409-23.

20.  Sk S, Biswas S, Dutta N, Das A, Suryadevara N, Vijaykumar G, Bhunia P, Ruben M, Mandal S, Bera M*. Structures and properties of a series of high-spin [CoII2] complexes supported by ancillary benzoate, ortho-hydroxybenzoate, and para-hydroxybenzoate ligands. Crystal Growth & Design. 2023 Jun 29;23(8):5925-40.

21.  Majumder A, Sarkar C, Das I, Sk S, Bandyopadhyay S, Mandal S*, Bera M*. Design, synthesis and evaluation of a series of zinc (II) complexes of anthracene-affixed multifunctional organic assembly as potential antibacterial and antibiofilm agents against methicillin-resistant Staphylococcus aureus. ACS applied materials & interfaces. 2023 May 2;15(19):22781-804.

22.  Dastidar DG*, Singh P, Bhattacharjee R, Ghosh D, Banerjee M, Biswas S, Mukherjee SK, Mandal S*. Development of Copper Nanoparticle Conjugated Chitosan Microparticle as a Stable Source of 2nm Copper Nanoparticle Effective against Methicillin-resistant Staphylococcus aureus. Pharmaceutical Nanotechnology. 2022 Aug 1;10(4):310-26.

23.  Mandal S*, Bandyopadhyay S, Tyagi K, Roy A*. Human microbial dysbiosis as driver of gynecological malignancies. Biochimie. 2022 Jun 1;197:86-95.

24.  Mandal S*, Bandyopadhyay S, Tyagi K, Roy A*. Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2021 Dec 1;1876(2):188619.

25.  Tyagi K, Mandal S, Roy A*. Recent advancements in therapeutic targeting of the Warburg effect in refractory ovarian cancer: a promise towards disease remission. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2021 Aug 1;1876(1):188563.

26.  Ghosh M*, Biswas S, Roy M, Biswas S, Ghosh P, Koner S*, Mandal S*, Saha S*. A trinuclear Zn (ii) Schiff base azido compound: synthesis, structure and exploration of antimicrobial activity. New Journal of Chemistry. 2021;45(27):12296-304.

27.  Dey S, Mukherjee D, Sultana SS, Mallick S, Dutta A, Ghosh J, Hussain A, Sarkar B, Mandal S, Patra P, Saha B, Pal C*. Combination of Mycobacterium indicus pranii and heat-induced promastigotes cures drug-resistant Leishmania infection: critical role of interleukin-6-producing classical dendritic cells. Infection and immunity. 2020 May 20;88(6):10-128.

28.  Mandal S, Mallick S, Maiti S, Bandyopadhya C, Pal C*. Induction of ROS by a novel chromone linked nitrone derivative promotes mitochondria mediated caspase dependent apoptosis in HepG2 and HeLa cells. World Scientific News. 2018(103):167-85.

29.  Mukherjee D, Singh CB, Dey S, Mandal S, Ghosh J, Mallick S, Hussain A, Swapana N, Ross SA, Pal C*. Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress. Brazilian Journal of Infectious Diseases. 2016;20(1):48-55.

30.  Mallick S, Dey S, Mandal S, Dutta A, Mukherjee D, Biswas G, Chatterjee S, Mallick S, Lai TK, Acharya K, Pal C*. A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani. Future microbiology. 2015 May 1;10(5):763-89.

31.  Yousuf M, Mukherjee D, Pal A, Dey S, Mandal S, Pal C*, Adhikari S*. Synthesis and biological evaluation of ferrocenylquinoline as a potential antileishmanial agent. ChemMedChem. 2015 Mar;10(3):546-54.

32.  Mallick S, Dutta A, Dey S, Ghosh J, Mukherjee D, Sultana SS, Mandal S, Paloi S, Khatua S, Acharya K, Pal C*. Selective inhibition of Leishmania donovani by active extracts of wild mushrooms used by the tribal population of India: an in vitro exploration for new leads against parasitic protozoans. Experimental Parasitology. 2014 Mar 1;138:9-17.

B. Books:

1.     Mandal S. Microbes and Sustainable Development. Nectar Publications, Kolkata. ISBN: 978-93-84077-28-7.

2.     Mandal S. The Protista. Nectar Publications, Kolkata. ISBN: 978-93-94077-13-3.

3.     Mandal S. Soil Microbiology. Nectar Publications, Kolkata. ISBN: 978-93-94077-11-9.

4.     Mandal S. Aquatic Microbiology. Nectar Publications, Kolkata. ISBN: 978-93-94077-16-4.

5.     Mandal S. Microbes in Genetic Engineering. Nectar Publications, Kolkata. ISBN: 978-93-94077-09-6.

6.    Mandal S. Leishmania: Pathogenesis, Treatment and Prevention. Nectar Publications, Kolkata. ISBN: 978-93 94077-15-7.

7.    Mandal S. Air Microbiology. Nectar Publications, Kolkata. ISBN: 978-93-94077-00-3.

8.    Mandal S. Apoptosis and Cancer: Physiology and Pathology. Nectar Publications, Kolkata. ISBN: 978-93-94077-14-0.

9.    Mandal S. Autoimmune Diseases: Physiology, Pathogenesis and Therapy. Nectar Publications, Kolkata. ISBN: 978-93-94077-01-0.

10. Mandal S. Basics of Bioenergetics. Nectar Publications, Kolkata. ISBN: 978-93-94077-02-7.

11. Mandal S. Food Microbiology. Nectar Publications, Kolkata. ISBN: 978-93-94077-07-2.

12. Mandal S. Gene Therapy: Basic Principles and Therapeautic Strategies. Nectar Publications, Kolkata. ISBN: 978-93-94077-08-9.

C. Book Chapters:

1.     Mandal S, Roy A. Ganoderma: A Pharmacological Mushroom with Remarkable Potency in Human Gut Microflora Dysbiosis. Ganoderma (pp. 106-117). CRC Press.

eBook ISBN: 9781003354789.

2.     Marine Microorganisms: New Frontier in Antimicrobial Therapeutics for the book Recent Trends and The Future of Antimicrobial Agents. Bentham Science Publishers, Singapore. ebook ISBN: 9789815079609.

3.     Mandal S, Kumar S. Microbe-Mediated Xenobiotic Degradation: Recent Status and Prospects. Plant-Microbe Interaction under Xenobiotic Exposure. Springer Nature. 2025 Jul 27:283-303. eBook ISBN: 978-981-96-8260-7.

D. Conferance and Seminar Presentations:

International (Abroad)

1. Paper presentation at the Pathobiology for Investigators, Students & Academicians (PISA) Conference, organised by the American Society for Investigative Pathology (ASIP), University of Pittsburgh, PA, USA (September 2017).

International (Within India)

1. Paper presentation at Contemporary Ideas, Innovations and Initiatives in Chemical Sciences (CI3CS-2023), Department of Chemistry, Presidency University, Kolkata (August 2023).

2. Paper presentation at the International Seminar on Current Advancements in Modern Biology, University of Gour Banga (October 2024).

3. Paper presentation at the International Conference on Plant Science: Today and Tomorrow, Department of Botany, University of Calcutta (December 2024).

4. Paper presentation at the ASM–IISc Symposium on the One Health Approach to Antimicrobial Resistance (AMR), Indian Institute of Science, Bangalore (October–November 2025).

National

1. National Level Seminar on Rediscovering 100 Years of Journey in Immunology, Barasat Government College & WBSU (September 2011).

2. National Conference on CME in Immunology, WBSU & Indian Immunology Society, New Delhi (November 2011).

3. 1st National Conference on Advancing Biology Through Technology and Computation, Department of Microbiology, WBSU & Kingston College of Science (August 2014).

4. National Conference on Stress Response and Diseases, Department of Biochemistry & Biophysics, University of Kalyani (March 2020).

State / University Level

1. 1st Regional Science & Technology Congress, Dept. of Science & Technology, Govt. of West Bengal & NITTTR, Kolkata (November 2016).

2. 4th Regional Science & Technology Congress, MAKAUT, West Bengal (December 2019).

3. Seminar on Claws of COVID-19, Dept. of Microbiology, St. Paul’s Cathedral Mission College (August 2020).

4. 5th Regional Science & Technology Congress, West Bengal State University (January 2023).

5. 6th Regional Science & Technology Congress, University of Calcutta (December 2023).

6. 7th Regional Science & Technology Congress, Bidhan Chandra Krishi Viswavidyalaya (BCKV) (January 2025).