Sutapa Saha

Assistant Professor

B. Sc. Physiology (Hons.), Physics, Chemistry (Presidency College, Kolkata, 2002)

M. Sc. Biophysics, Molecular Biology & Genetics (CU, Kolkata, 2004)

Post M. Sc. Associateship Course in Biophysical Sciences (SINP, Kolkata, 2005)

Ph.D. Life Sciences on 'Proteomic Studies in a Haematological Malignancy: B-cell Acute Lymphoblastic Leukemia' (SINP, HBNI, India, 2012)

Dr. Saha developed a fascination towards scientific research during her M.Sc days at the Department of Biophysics, Molecular Biology & Genetics, CU (CUBMB). She will always be grateful to her teachers at CUBMB for their everlasting encouragement and inspiration that motivated her towards a career in science and scientific research. 

Dr. Saha's doctoral work at the Structural Genomics Division, SINP, Kolkata, encompassed ‘Clinical proteomics in haematological malignancies and erythrocyte disorders’. She is fascinated with the power of ‘omic’ technologies (proteomics/transcriptomics) in revealing disease-pathogenesis in a holistic perspective. She has an appetite for ‘quality-science’ and, wants to actively contribute to the advancement of biomedical science in India in the future.

As part of my doctoral research programme, I gathered 6 years experience in ‘clinical proteomic study of haematological malignancies and erythrocyte disorders’. During this tenure, I had a complete training in cutting-edge technologies like Mass Spectrometry & Protein Sequencing, Difference In Gel Electrophoresis (DIGE), Multiparametric Flow Cytometry, Immuno-magnetic cell sorting (MACS), Confocal Microscopy, Electron Microscopy, RT-PCR, etc. 

My future research interests include –

• Molecular mechanisms of genetic/epigenetic regulation in hematopoiesis, leukemogenesis, trans-differentiation or lineage switch, & tumour reversion

• Mechanism of circadian dysfunction in leukemia

• Biomedical applications of Proteomics and Biological Mass Spectrometry, etc.

My teaching interests include but are not restricted to – recombinant DNA technology; human genetics; biochemistry; molecular biology; immunology; cell signalling; proteomics and mass spectrometry; cancer biology.

I am interested to supervise motivated M.Sc students (preferably CSIR/UGC-NET qualified) for PhD. The research focus would be on-

• Molecular mechanisms of genetic/epigenetic regulation in hematopoiesis, leukemogenesis, trans-differentiation or lineage switch, & tumour reversion

• Mechanism of circadian dysfunction in leukemia

• Biomedical applications of Proteomics and Biological Mass Spectrometry, etc.

Member of the Human Proteome Organization (HUPO); 2012

Sessional Member of The Indian Science Congress Association (ISCA); 2012-13

The 'Not-So-Famous Five' in tumorigenesis: tRNAs, tRNA fragments, and tRNA epitranscriptome in concert with AARSs and AIMPs. S Saha, B Mukherjee, P Banerjee, D Das, Biochimie, 2024, 222:45-62. doi: 10.1016/j.biochi.2024.02.004.

Green Biotechnology for Sustainable Development and Climate Change. S. Saha, S. Pal, S. Das, P. Hazra Dutta, A Mukhopadhyay, Biofuels: Scientific Explorations and Technologies for a Sustainable Environment, 2024 (1st ed.), CRC Press, eBook ISBN 9781003350606. 

Spectrin interactome under normal and HbE-disease conditions. D Bose, Sk R Islam, S Saha & A Chakrabarti, Journal of Proteins and Proteomics, 2020, 11(4):1-8.

Biophysical and theoretical studies of the interaction between a bioactive compound 3,5-dimethoxy-4- hydroxycinnamic acid with calf thymus DNA. P Mondal, P Sengupta, U Pal, S Saha, A Bose, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 245, 118936.

Differential proteomics study of platelets in asymptomatic constitutional macrothrombocytopenia: altered levels of cytoskeletal proteins. S. Karmakar, S. Saha, D. Banerjee, A. Chakrabarti, European Journal of Haematology, 2015, 94, 43-50.

Comparative proteomics and glycoproteomics of plasma proteins in Indian visceral leishmaniasis. A. K. Bag, S. Saha, S. Sundar, B Saha, A. Chakrabarti, C. Mandal, Proteome Science, 2014, 12, 48.

2DGE and DIGE based proteomic study of malignant B-cells in B-cell Acute Lymphoblastic Leukemia. S. Saha, S. Banerjee, D. Banerjee, S. Chandra, A. Chakrabarti, EuPA Open Proteomics, 2014, 3, 13-26.

2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: altered proteostasis and oxidative stress. A. Basu, S. Saha, S. Karmakar, S. Chakravarty, D. Banerjee, B.P. Dash, A. Chakrabartii, Proteomics, 2013, 13, 3233-3242.

Fractional precipitation of plasma proteome by ammonium sulphate: case studies in leukemia and thalassemia. S. Saha, S. Halder, D. Bhattacharya, D. Banerjee, A. Chakrabarti, Journal of Proteomics and Bioinformatics, 2012, 5(5), 163-171.

Elevated levels of redox regulators, membrane bound globin chains and cytoskeletal protein fragments in hereditary spherocytosis erythrocyte proteome. S. Saha, R. Ramanathan, S. Basu, D. Banerjee, A. Chakrabarti, European Journal of Haematology, 2011, 87, 259-266.

Differential expression of red cell proteins in hemoglobinopathy. A. Chakrabarti, D. Bhattacharya, A. Basu, S. Basu, S. Saha, S. Halder, Proteomics-Clinical Applications, 2011, 5, 98-108.

Differential regulation of redox proteins and chaperones in HbE?-thalassemia erythrocyte proteome. D. Bhattacharya, S. Saha, S. Basu, S. Chakravarty, A. Chakravarty, D. Banerjee, A. Chakrabarti, Proteomics-Clinical Applications, 2010, 4, 480–488.

Oxidative crosslinking, spectrin and membrane interactions of hemoglobin mixtures in HbEbeta-thalassemia. A. Chakrabarti, P. Datta, D. Bhattacharya, S. Basu, S. Saha, Hematology, 2008, 13, 361-368.

Porous red cell ultrastructure and loss of membrane asymmetry in a novel case of hemolytic anemia. D. Banerjee, S. Saha, S. Basu, A. Chakrabarti, European Journal of Haematology, 2008, 81, 399-402.