Mayukh Biswas

Assistant Professor

Molecular Epigenetics in Hematopoiesis and Hematological Malignancies

My long-standing scientific interest is to understand the epigenetic plasticity associated with tumor initiation and progression, specifically in the context of hematologic malignancies. As a child, I was always fascinated by the different diseases that create havoc in human mankind and wanted to find solutions for them. As I grew up, my interest became much stronger which ultimately motivated me to pursue Integrated M.Sc. in the field of Biotechnology at St. Xavier's College, Kolkata. Following this to gain in-depth knowledge, I went on to pursue research in the field of hematological malignancies namely Acute Myeloid Leukemia (AML), the most common acute blood cancer in adults, and T- Acute Lymphoblastic Leukemia (T-ALL), an aggressive malignant neoplasm of the bone marrow which accounts for ∼20% of all cases of acute lymphoblastic leukemia (ALL).

During my Ph.D. I have worked on the epigenetic regulation of hematopoietic stem cells in AML at CSIR - Indian Institute of Chemical Biology (IICB), Kolkata. My study focused on elucidating and understanding the cellular and molecular mechanisms by which NuRD and SWI/SNF complexes regulate the epigenetic landscape of MDS and AML. My postdoctoral studies at Institute for Cancer Genetics at Columbia University Medical Center, New York aimed to identify and mechanistically dissect driver pathways involved in ALL malignant proliferation and survival. My research focused on identifying specific epigenetic mechanisms and collateral vulnerabilities associated with the loss of PHF6 in T-ALL.

In the future as an independent investigator, I aim to carry out fundamental research in understanding the role of epigenetic factors misregulated in various human diseases and especially cancer. My research area will focus on identifying the underlying mechanisms behind the epigenetic plasticity associated with ATP-dependent chromatin remodeling complexes in hematological malignancies. Our studies will amalgamate genomic and epigenomic profiling, transcriptomics, cellular and biochemical assays to functionally dissect the molecular connections between chromatin organization and dysregulation of gene expression in human cancers.

Address

Presidency University,
86/1 College Street, Kolkata - 700073,
West Bengal, India

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Email: mayukh.ihs at presiuniv.ac.in
alternate E-mail: mayukhbiswas.89 at gmail.com

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