Paramita Saha

Assistant Professor

I am a Cell and Molecular Biologist by training and currently working on two different diseases, Polycystic Ovary Syndrome (PCOS) and Cancer.  Thus, our lab is a "Molecular Endocrinology and Cancer Biology" lab. 

My Doctoral and initial Post-Doctoral studies focussed towards unraveling the cellular dynamics of HABP1, the multifunctional human protein identified by our lab and implicated in several cellular functions and diseases; in cancer progression and metastasis. I studied the signal transduction mechanism of the evolutionarily conserved cellular process of autophagy in conjunction with the hyaladherin named, Hyaluronan-binding protein 1 (HABP1/p32/gC1qR).  These work helped towards establishing, that the elevated expression of HABP1 undoubtedly leads to enhanced HA synthesis, HA cable formation modifying the tumor potency in HepG2 cells. From my work on autophagy in the fibroblasts and hepatocarcinoma cell lines, I was able to establish a link between ectopic expression of HABP1, ROS generation and the homeostatic mechanism of autophagy, which is an associated phenomena during cancer progression. 

Later on, I started my journey as an Independent Researcher (Young Scientist, SERB, DST) at the Molecular Endocrinology Laboratory, Special Centre for Molecular Medicine, Jawaharlal Nehru University and started working in the field of reproductive biology. The project focussed on elucidating the incidence and impact of autophagy and also the probable role of the nuclear receptor, Androgen Receptor.

My ongoing research areas of interests are as follows:

  • Understanding HABP1-SRSF1 dynamics  and its  implications  on granulosa cell tumorigenesis.
  • Studying the signal transducing mechanism leading to increased incidence of autophagy in Polycystic Ovarian Syndrome (PCOS) and potential therapeutic intervention
  • Analyzing the impact of polycystic ovarian conditions on glycolytic enzymes and tumor promoting factors

 

Address

Presidency University,
86/1 College Street, Kolkata - 700073,
West Bengal, India

CV Not Available
Email: paramitasaha.dbs at presiuniv.ac.in
alternate E-mail: paramitasaha12 at gmail.com

How to Find Us

Presidency University
(Main Campus)

86/1 College Street
Kolkata 700073

Presidency University
(2nd Campus)

Plot No. DG/02/02,
Premises No. 14-0358, Action Area-ID
New Town
(Near Biswa Bangla Convention Centre)
Kolkata-700156
Contact details Presidency University Students Corner

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