Current vacancy for immidiate fill-up: M.Sc. passed NET/GATE qualified candidates with organic chemistry background are encouraged to contact Dr. Koena Ghosh for project JRF position on full-time basis. Advertisement for project JRF https://www.presiuniv.ac.in/web/walkinchemkohena060320241.php
Date of interview: 02.04.2024
Last date of application: 28.03.2024
- Ph.D. position available: Highly motivated NETqualified candidates with organic chemistry background are encouraged to contact Dr. Koena Ghosh for Ph.D. on full-time or part-time basis.
- Post-doctoral position (candidates having own fellowship): Interested candidates may also contact for submission of new projects with us.
email: koena.chem@presiuniv.ac.in
==============
I am a synthetic organic chemist experienced in asymmetric synthesis and exploration of small organic molecules in medicinal chemistry. I teach basic and advanced courses in chemistry (organic) at UG, PG and Ph.D. level. In an academic institution, my priority will be to train students for a successful career in chemistry.
===============
Research Interest:
Dr. K. Ghosh’s group research activities aim to address synthetic challenges associated with (i) stereoselective functionalization of organic molecules (ii) sustainable methodology development using catalytic chemistry. Another domain of research explores synthesis and application of small molecules in medicinal chemistry. Our ongoing research explores the following areas:
- Synthesis and exploration of ferrocenyl N-heterocycles as fluorescent based medicinally important pharmacophores (as cancer therapeutics).
- Development of sustainable methodology for industrially important organic transformations (using cost effective water soluble catalyst / solid supported catalytic system, unconventional solvents etc.).
- Design and synthesis of chiral N-heterocyclic carbene for stereo-controlled C-H bond activation / cyclisation reactions etc. (using metal or non-metal based catalysts).
Research project:
Completed:
Title: "Design and Synthesis of Chiral NHC Ligands for Asymmetric eactions" (2013-2017)
Principal Investigator: Koena Ghosh
Funded by: Sciene and Engineering Board (SERB), DST, India.
Ongoing:
Title: "Stereoselective Synthesis of Fused Oxa/Aza-heterocycles......of Donor-Acceptor Cyclopropanes" (2018)
Principal Investigator: Koena Ghosh
Funded by: Council of Scientific and Industrial Research (CSIR), India
Ph.D. (2003-2009) in Synthetic organic chemistry from Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, INDIA; Thesis title: "Memory of Chirality (MOC) in Imino-aldol Reaction: Enantioselective Synthesis and Lewis Acid Mediated SN2-type Ring-opening of Aziridines”; Mentor: Prof. Manas K Ghorai.
M.Sc. (2002) in Chemistry), University of Calcutta, Kolkata, INDIA.
B.Sc. (2000) Chemistry (Hons ), University of Calcutta, Kolkata, INDIA.
Dr. Koena Ghosh obtained her Ph.D. in synthetic organic chemistry (focusing on asymmetric synthesis) at Indian Institute of Technology Kanpur, India in the group of Prof. Manas K Ghorai in 2009 and thereafter moved to Purdue University, USA for a post-doctoral training on medicinal chemistry in the group of Prof. Arun K Ghosh. After coming back in India, in 2011, she joined Indian Association for the Cultivation of Science (IACS), Kolkata as a Research Associate (laboratory of Prof. Amitabha Sarkar) and worked on asymmetric catalysis. During this period she visited University of Nottingham, UK (laboratory of Prof. Simon Woodward) as a visiting British Council Fellow. In 2012, Dr. Ghosh moved to Bangalore, India with a industrial position (team leader) and handled medicinal chemistry project in the general area of virology at BMS Biocon R & D Centre (BBRC) at Syngene Intl. Ltd. Later on, in August 2013, she joined as a Young Scientist (under DST Fast Track scheme) at Indian Institute of Technology Kharagpur (laboratory of Prof. Amit Basak). In November, 2013, she joined the Department of Chemistry, Presidency University as an Assistant Professor.
14 years post Ph.D. research experience in organic synthesis focusing on asymmetric synthesis, syntheyic & mechanistic exploration of small ring aza-heterocycles, asymmetric catalysis and medicinal chemistry. Firther, I have industrial research experience (R & D) on drug design and development in virology.
DST Young Scientist (Fast Track Project), Department of Chemistry, IIT Kharagpur (laboratory of Prof. Amit Basak); 2013
Industrial Experience: Research Investigator (Project Leader, Medicinal Chemistry Project on Hepatitis B), Biocon Bristol-Myers Squibb Research & Development Center (BBRC), Bangalore, 2012
Post Doctoal Experience:
Post Doctoral Research Associate, Department of Chemistry, Purdue University, USA (Mentor: Prof. Arun K Ghosh)
Research Associate, Department of Organic Chemistry, Indian Association for the Cultivation of Science (IACS), Kolkata (laboratory of Prof. Amitabha Sarkar)
Visiting Research Associate, School of Chemistry, University of Nottingham, UK (laboratory of Prof. Simon Woodward)
Research interest:
Development of synthetic methodology employing catalytic chemistry to access carbo or hetecycles of medicinal/industrial importance
Asymmetric catalysis (design and synthesis of chiral N-heterocyclic carbene for asymmetric tranbsformation)
Synthesis of ferrocene-N heterocycle conjugates as fluorescent probe useful in biology and material sciences.
Organic transformation in aqueous media: A greener approach
Research project as PI
Completed:
Title: "Design and Synthesis of Chiral NHC Ligands for Asymmetric eactions" (2013-2017)
Principal Investigator: Koena Ghosh
Funded by: Science and Engineering Board (SERB), DST, India (Fast Track scheme)
Ongoing:
Title: "Stereoselective Synthesis of Fused Oxa/Aza-heterocycles via Domino Ring-opening Cyclization of Donor-Acceptor Cyclopropanes" (2018)
Principal Investigator: Koena Ghosh
Funded by: Council of Scientific and Industrial Research (CSIR), India
Teaching Experience: Teaching basic and advance level courses at UG and PG level in organic chemistry. I am also mentoring MSc project, project trainees and Ph.D. students. Students after receiving basic research training in organic synthesis are well placed and motivated to pursue their research career.
Theory Courses
Under Graduate level:
- Basic idea of pericyclic reaction (based on FMO approach) (CHEM 0601)
- Basic concept on asymmetric synthesis (1,2-asymmetric induction) (CHEM 0501)
- Enolate Chemistry (synthetic application) (CHEM 0501)
- Reaction mechanism (substitution, elimination etc.) (CHEM 0302 & CHEM 0402)
- Carbonyl reduction and its synthetic application (CHEM 0401)
Post Graduate level:
- Advance course on Asymmetric Synthesis (CHEM 1001A)
- Advance couse on Pericyclic reactions (CHEM 0701)
- Stereochemistry of polycyclic systems (CHEM 0901A)
- Chemistry of natural products (stereochemistry, reactions of terpeniods and steroids) (PG I) (CHEM 0801)
Practical Courses
Under Graduate level:
- Synthesis-based Practical ( Two step organic synthesis) (CHEM 0591)
- Quantitative estimation and chromatographic separation (CHEM 0691)
Post Graduate level:
- Separation of binary mixtures (organic practical) (CHEM 0891)
- Preparation of organic compounds (Organic Special Practical-I) (CHEM 0991)
Student trained for research
Mentoring M.Sc. Project Students
- Wasim Akhtar (2022)
- Ranjeeta Naskar (2021)
- Samyak Sahu (2021)
- Rizwana Parveen (2020)
- Oindrila Adhikari (2019)
- Pikaso Latua (2019)
- Kaushik Singha (2019)
- Arin Bhakat (2018); joined Ph.D. programme at IIT-Gawahati
- Sourav Jana (2016); working at TCG Lifesciences Private Limited Chembiotek
- Sudeshna Roy (2016)
- Soumen Sarkar (2015); Current position: Chemist, ONGC Ltd., India
- Rima Saha (2015); joined Ph.D. programme at University of Calcutta, Kolkata
- Payel Datta (2014); joined Ph.D. programme at Kent State University, USA
- Sayan Sarkar (2014); joined Ph.D. programme at IACS, Kolkata
- Kousik Gayen (2013); joined Ph.D. programme at IACS, Kolkata
- Leena Majumder (2013)
Student trained under EMR projects/others
- Subhajit Dhara (DST project)
- Nipa Nayek (short term trainee)
- Ishani Bose (summer trainee)
- Anik Dutta (CSIR project)
Other Experience:
Industrial experience: ~1 year industrial experience in the BMS Biocon R & D Centre (BBRC), A Biocon Company, Bangalore as a Research Investigator (project leader) and handled medicinal chemistry project in the general area of virology.
Study material:
UG course:
DEC-Sem 6_2022: Lecture 1-3 (https://k00.fr/qwo1wcnw | password: 154594)
Publications:
Journals
Koena Ghosh,* Nipa Nayek, Subhomoy Das, Nabendu Biswas, Samraj Sinha (2021); "Design and synthesis of ferrocene?tethered pyrazolines and pyrazoles: Photophysical studies, protein?binding behavior with bovine serum albumin, and antiproliferative activity against MDA?MB?231 triple negative breast cancer cells" Appl. Organomet. Chem. (DOI: 10.1002/aoc.6248); https://doi.org/10.1002/aoc.6248
Koena Ghosh,* and Subhomoy Das (2021); "Recent advances in ring-opening of donor
acceptor cyclopropanes using C-nucleophiles" Org. Biomol. Chem., 19, 965-982. (DOI: 10.1039/d0ob02437f)
Koena Ghosh,* Shubhajit Dhara, Sourav Jana, Subhomoy Das and Sudeshna Roy (2019)
"NHC Stabilized Pd Nanocluster in Mizoroki-Heck Reaction within Microemulsion: Exploring the Role of Imidazolium Salt on Rate Enhancement" New Journal of Chemistry, 43, 1993-2001. (DOI: 10.1039/c8nj05118f)
Arun K. Ghosh*, Koena Ghosh, Margherita Brindisi, Emma K. Lendy, Yu-Chen Yen,
Nagaswamy Kumaragurubaran, Xiangping Huang, Jordan Tang, Andrew D. Mesecar (2018) "Design, synthesis, X-ray studies, and biological evaluation of novel BACE1
inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand" Bioorg. Med. Chem. Lett., 28, 2605–2610. (DOI: 10.1016/j.bmcl.2018.06.045)
Vadlamuri Veeraswamy, Gaurav Goswami, Satobhisha Mukherjee, Koena Ghosh, Manik Lal
Saha, Arunava Sengupta and Manas K. Ghorai* (2018) "Memory of Chirality (MOC) Concept in Asymmetric Intermolecular Michael Addition of α-Amino Ester Enolates to Enones and Nitroalkenes" J. Org. Chem. 83, 1106−1115. (DOI: 10.1021/acs.joc.7b02315)
Ansuman Bej, Koena Ghosh, Amitabha Sarkar* and David. W. Knight* (2016) "Palladium nanoparticles in the catalysis of coupling reactions" RSC Advance, 6, 11446–11453. (DOI: 10.1039/c5ra26304b)
Debaki Ghosh, Subhanep Biswas, Koena Ghosh and Amit Basak* (2014) "Garratt–Braverman cyclization on basic alumina: a green protocol with improved selectivity" Tetrahedron Lett., 55, 3934-3937. (DOI: 10.1016/j.tetlet.2014.05.033)
Hao Wu, Deborah Downs, Koena Ghosh, Arun K. Ghosh, Peter Staib, Michel Monod and Jordan Tang* (2013). “Candida albicans secreted proteases 4-6 induce apoptosis of epithelial cells by a novel ‘Trojan Horse Mechanism”; The FASEB J. 27, 2132-2144. (DOI: 10.1096/fj.12-214353)
Manas K Ghorai*, Koena Ghosh, A. K. Yadav, Y Nanaji, S. Haldar and M. Sayyd; (2013). “Memory of Chirality (MOC) concept in imino-aldol reaction: Enantioselective synthesis of α, β-diamino esters and aziridines” (article). J. Org. Chem. 78, 2311-2326. (DOI: 10.1021/jo302018a)
Manas K. Ghorai*, Koena Ghosh, A. K. Yadav. (2009) “Enantioselective synthesis of a,b-diamino ester derivatives: memory of chirality in imino-aldol reactions”. Tetrahedron Lett., 50, 476-479.(DOI:10.1016/j.tetlet.2008.11.050)
Manas K. Ghorai* and Koena Ghosh. (2007) “Lewis acid mediated nucleophilic ring opening followed by cycloaddition of 2-aryl-Ntosylaziridines with carbonyl compounds: further support towards an SN2-type mechanism”. Tetrahedron Lett., 48, 3191-3195. (DOI:10.1016/j.tetlet.2007.03.042)
Manas K. Ghorai,* Koena Ghosh and Kalpataru Das (2006) "Copper(II) triflate promoted cycloaddition of a-alkyl or aryl substituted N-tosylaziridines with nitriles: a highly efficient synthesis of substituted imidazolines" Tetrahedron Lett., 47, 5399-5403. (DOI: 10.1016/j.tetlet.2006.05.059)
Manas K. Ghorai,* Kalpataru Das, Amit Kumar and Koena Ghosh (2005) "An efficient route to regioselective opening of N-tosylaziridines with zinc(II) halides" Tetrahedron Lett., 46, 4103-4106. (DOI: 10.1016/j.tetlet.2005.04.006)
Presidency University Students Corner