Anjoy Majhi

Assistant Professor

The utilization of invasive biopsies of normal tissues (i.e., brain, heart, etc.) is prohibitive in humans due to obvious reasons of traumatism and morbidity. Therefore there is a need of development of non-invasive technique to evaluate different cell activity in tumors in vivo before and during therapy. Histone deacetylases (HDACs), a group of epigenetic enzymes that modulate chromatin activity by removing acetyl groups from the lysine residues of histones, have received worldwide attention as anticancer targeted molecules. Targeting HDAC will be helpful to diagnose as well as treatment of cancer. The development of fluorescent probe by using HDAC (histone deacetylase) inhibitor as a marker compound might be a powerful tool for studying cancer biology. This will be particularly useful for investigating, cancer diagnosis, treatment as well as prognosis of the disease So in true sense I would like to synthesize several biologically active small molecule which may be fluorescent labeled and can be utilized as a fluorescent probe/imaging agent (non-invasive technique) for studying cancer biology. Besides, I am also interested to synthesize and characterize of several thienopyrimidine compound and polyphenolic compoundand which can be used as fluorescent probe. Novel chemical strategy will be used for synthesis. The structure activity relationship will be tested in vitro and in vivo. The potency, toxicity and specificity of analogs will be tested using different cancerous cell lines and animal models with collaborative group in our institute/other institute.


Presidency University,
86/1 College Street, Kolkata - 700073,
West Bengal, India

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Presidency University
(Main Campus)

86/1 College Street
Kolkata 700073

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(2nd Campus)

Plot No. DG/02/02,
Premises No. 14-0358, Action Area-ID
New Town
(Near Biswa Bangla Convention Centre)
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