My lab's research focus is structure function characteristion of macromolecules involved in the pathogenesis of diseases in humans and plants. This includes unravelling the molecular mechanisms of host-pathogen interactions, epigenetic regulations in host system under stress conditions etc. To achieve these interests, we are using different combinations of biochemical, biophysical and computational methods in our laboratory. Our lab is well funded by DBT and DST grants, FRPDF (WB Govt).
Our lab is always looking for enthuasiastic students (preferably qualified DBT/ICMR/UGC/CSIR NET-JRF) who have done their MSc in lifesciences/Biochemistry/Chemistry/Botany. CSIR NET-LS students are also welcome to apply. If you are interested in this exciting research, you can contact me @ firstname.lastname@example.org
Currently, there is opening for TWO CSIR/UGC NETJRF candidates for a DST-SERB funded project: "Molecular mechanisms of rice sirtuin actions under stress conditions". Interested candidates can email me their applications to email@example.com
PhD Biochemistry (Texas A&M University, USA, 2008)
BEd (Nagpur University, 1998)
MSc (Biochemistry) Nagpur University, 1997
BSc (Biochemistry, Chemistry, Zoology) Nagpur University,1995
Assistant Professor (Dept. of Life Sciences, Presidency University) 2013 -present
Postdoctoral Research Associate (Washington University in St Louis, Missouri) 2012-2013
Postdoctoral Research Associate (University of California, San Diego) 2008-2012
Research / Administrative Experience+
Teaching / Other Experience+
MSc students in Biological/Life Sciences, Presidency University, 2013- present
Courses teaching: Advanced Enzymology, Biophysical methods, Protein and RNA biochemistry, Protein engineering
MSc Thesis students:
(2021) Beas Mukherjee (PU), Shriya Bose (CU)
(2020) Shinjini Ghosh (CU), Shreya Laha (CU), Shibam Banerjee (PU), Ankita Das (PU)
(2019) Atreyee Mukherjee (PU), Tapas Sardar (CU), Souvik Saha (CU)
(2018) Izaz Monir Kamal (PU), Souraj Banerjee (CU)
(2016) Adrija Basak (PU), Priti Agarwal (PU)
(2015) Manisha Adhikary, Sargam Chopra
BSc students in Biological Sciences, Presidency University, 2013 - present
Courses teaching: Protein chemistry, Enzymology, Intermediate Metabolism, Biophysical methods and applications
Undergraduate students (BSc Honors) in Biochemistry, Presidency University 2013 - 2015
Courses taught: Enzyme kinetics, DNA repair mechanisms, Metabolism
Undergraduate students in Biochemistry (Teaching assistant, Texas A&M University, Texas, USA) 2001-2002
Undergraduate students in Biotechnology (LAD College, Nagpur University) 1998-2000
MSc students in Biochemistry (Department of Biochemistry, Nagpur University) 1997-2000
Post Graduate Supervision+
Current PhD Students:
Nilabhra Mitra (2014-present): working on "Molecular mechanisms of Sirtuin in disease pathogenesis" Registered in PU
Sonali Khan DST-SERB Junior Research Fellow (2020-present): "Structural and Biochemical characterization of a class III sirtuin OscobB in Oryza sativa indica and its association to stress response in plants". Registered in PU
Joykesh Roy Barman CSIR- NET JRF (2020- present): "Structure function dissection of class II sirtuin member in Oryza sativa indica, OsSRT2". Registered in PU
TB structural genomics consortium (USA)
11. Mitra N, Dey S (2019), " Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation" Archives of Biochemistry and Biophysics; 10.1016/j.abb.2019.108226
10. Yi H*, Dey S*, Kumaran S, Lee SG, Krishnan HB, Jez JM (2013), "Structure of soybean serine acetyltransferase and formation of the cysteine regulatory complex as a molecular chaperone", J Biol Chem.; 288(51):36463-72 * equal contribution
9. Arambula D, Wong W, Medhekar BA, Guo H, Gingery M, Czornyj E, Liu M, Dey S, Ghosh P, Miller JF (2013). Surface display of a massively variable lipoprotein by a Legionella diversity generating retroelement. PNAS;110(20): 8212-17
8. Jez JM, Dey S (2013). The cysteine regulatory complex from plants and microbes: what was old is new again. Current opinion in Structural Biology;23: 302-10.
7. Alayyoubi M, Guo H, Dey S, Miller JF, Ghosh P (2013). Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase. Structure; 21(2): 266-76.
6. Musgrave WB, Yi H, Kline D, Cameron JC, Wignes J, Dey S, Pakrasi HB, Jez JM (2012). Probing the Origins of glutathione biosynthesis throughout biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote. Biochemical Journal; 450(1): 63-72.
5. Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC (2010). Structural characterization of the Mycobacterium tuberculosis biotin biosynthetic enzymes 7, 8-Diaminopelargonic Acid synthase and Dethiobiotin synthetase. Biochemistry; 49(31): 6746-60.
4. Dey S, Burton RL, Grant GA, Sacchettini JC (2008). Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase. Biochemistry; 47(32): 8271-82.
3. Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA (2007). The effect of hinge mutationson effector binding and domain rotation in E.coli D-3-phosphoglycerate dehydrogenase. J Biol Chem.; 282(25):18418-26.
2. Dey S, Grant GA, Sacchettini JC (2005). Crystal structure of Mycobacterium tuberculosis D-3 phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits. J Biol Chem.; 280(15):14892-99. (On cover)
1. Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA (2005). D-3 phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. J Biol Chem.; 280(15):14884-91.
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